THE OLIVE LABORATORY
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    • A non-technical overview >
      • The Pancreas (Overview)
      • Pre-cancerous lesions (Overview)
      • Pancreatic Cancer (Overview)
      • Pancreatic Cancer Statistics
      • Symptoms and Diagnosis
      • Surgery for Pancreatic Cancer (Overview)
      • Drug Treatment (Overview)
      • Mouse Models (Overview)
      • Clinical Trials
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    • Join Us!
    • Oncology Precision Therapeutics Core >
      • MRI
      • Ivis Optical Imager
      • Vevo 3100 Ultrasound
      • Perkin-Elmer FX micro CT
    • Photos >
      • 10/30/19 Fall Fun
      • 6/29/18 Jaime's Last Day
      • 9/26/15 Mike's Wedding
      • 11/8/14 Carmine's Wedding
      • 7/7/14 Barbara's Temporary Goodbye Lunch
      • 4/26/13 Korean and Karaoke
      • 4/12/13 Purple Stride
      • 11/26/12 Pancreatic Cancer Awareness Week!!
      • 10/26/12 Pumpkin Carving
      • 9/5-7/2012 Olive and Kimmelman Lab Retreat
      • 7/13/12 Mid-summer BBQ
      • 3/29/12 Jennifer's Goodbye - BoardGame Night
      • 3/8/2012 Barbara's engagement celebration
      • 3/2/2012 Bowling
      • 12/18/2011 Holiday Party
      • 12/9/2011 Poker
      • 11/11/2011 Karaoke
      • 7/15/2011 Holiday Party
    • Support

Publications

curiel-garcia_a_decker-farrell_ar_sastra_sa_olive_kp._generation_of_orthotopic_patient-derived_xenograft_models_for_pancreatic_cancer_using_tumor_slices..pdf
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Badgley MA, Lee HJ, Maurer HC, Kremer D, Purohit V, Sajjakulnukit P, Firl CEM, Zhang L, Tolstyka ZP, Sastra SA, Palermo CF, DelGiorno KE, Decker A, Liu T, Gu W, Iuga A, Wahl GM, Seeley ES, Stockwell BR, Lyssiotis CA, Olive KP; “Modulation of cystine import induces pancreatic cancer-selective ferroptosis”, Science, April 2020 Vol. 368, Issue 6486, pp. 85-89. DOI: 10.1126/science.aaw9872
File Size: 1470 kb
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​Payen T, Oberstein PE, Sharkhiz N, Palermo CF, Sastra SA, Han Y, Nabavizadeh A, Sagalovskiy I, Orelli B, Rosario VI, Desrouilleres D, Remotti HE, Kluger MD, Schrope BA, Chabot JA, Iuga A, Konogafou EE,* Olive KP;* “Harmonic Motion Imaging of pancreatic tumor stiffness indicates disease state and treatment”, Clinical Cancer Research, DOI: 10.1158/1078-0432.CCR-18-3669 December 2019.
File Size: 2240 kb
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*Eberle-Singh JA, Maurer HC, Sastra SA, Palermo CF, Sagalovskiy I, Kim MJ, Sheedy J, Mollin A, Cao L, Hu J, Branstrom A, Weetall M, Olive KP; “Effective delivery of a microtubule polymerization inhibitor synergizes with standard regimens in models of pancreatic ductal adenocarcinoma”, Clinical Cancer Research, June 2019 Online
File Size: 4119 kb
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Maurer HC, Holmstrom SR, He J, Su T, Ahmed A, Hibshoosh H, Chabot JA, Oberstein PE, Sepulveda AR, Genkinger JM, Zhang J, Iuga AC, Bansal M, Califano A,* and Olive KP,* “Experimental microdissection enables functional harmonisation of pancreatic cancer subtypes”; Gut, Jan 2019 Advance online.
File Size: 8527 kb
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*Maurer, HC and Olive, KP. “Laser Capture Microdissection on frozen sections for extraction of high-quality nucleic acids”, Methods Mol Bio, 1882:253-259, 2019
File Size: 253 kb
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Arnes L*, Liu Z, Wang J, Carlo Maurer H, Sagalovskiy I, Sanchez-Martin M, Bommakanti N, Garofalo DC, Balderes DA, Sussel L, Olive KP, Rabadan R. “Comprehensive characterisation of compartment-specific long non-coding RNAs associated with pancreatic ductal adenocarcinoma”, Gut, Feb 2018, advance online. PMID: 29440233 Role: Oversaw laboratory component and contributed large-scale RNA-seq dataset; writing and editing.
File Size: 5410 kb
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Payen T, Palermo CF, Sastra SA, Chen H, Han Y, Olive KP,* Konofagou EE.* “Elasticity mapping of murine abdominal organs in vivo using harmonic motion imaging (HMI).” Phys Med Biol, 61(15): 5741-54, 2016. PMID: 27401609. Role: Oversaw in vivo studies and analysis of tissues; writing and editing.
File Size: 1962 kb
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Rhim AD*, Oberstein PE*, Thomas DH*, Mirek ET, Palermo CF, Sastra SA, Dekleva EN, Saunders T, Becerra CP, Tattersall IW, Westphalen CB, Kitajewski J, Fernandez-Barrena MG, Fernandez-Zapico ME, Iacobuzio-Donahue C, Olive KP, Stanger BZ. Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma. Cancer Cell. 2014 May 21. pii: S1535-6108(14)00184-6. doi: 10.1016/j.ccr.2014.04.021. [Epub ahead of print] PMID: 24856585
File Size: 7906 kb
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Olive KP1, Politi K. Translational therapeutics in genetically engineered mouse models of cancer. Cold Spring Harb Protoc. 2014 Feb 1;2014(2):131-43. doi: 10.1101/pdb.top069997.
File Size: 546 kb
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Sastra SA, Olive KP. Acquisition of Mouse Tumor Biopsies through Abdominal Laparotomy. Cold Spring Harb Protoc. 2014 Jan 1;2014(1). pii: pdb.prot077834. doi: 10.1101/pdb.prot077834. PMID:24371318
File Size: 808 kb
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Delgiorno KE, Hall JC, Takeuchi KK, Pan FC, Halbrook CJ, Washington MK, Olive KP, R Spence J, Sipos B, Wright CV, Wells JM, Crawford HC. Identification and Manipulation of Biliary metaplasia in pancreatic tumors. Gastroenterology. 2014 Jan;146(1):233-244.e5. doi: 10.1053/j.gastro.2013.08.053. Epub 2013 Aug 30. PMID:23999170
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Oberstein PE, Olive KP.Pancreatic Cancer: why is it so hard to treat. Therap Adv Gastroenterol. 2013 Jul;6(4):321-37. doi: 10.1177/1756283X13478680. PMID:23814611
File Size: 492 kb
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Chin L, de Sauvage F, Egeblad M, Olive KP, Tuveson D, Weiss W.Recapitulating Human cancer in a mouse. Nat Biotechnol. 2013 May;31(5):392-5. doi: 10.1038/nbt.2575. No abstract available. PMID:23657389
File Size: 315 kb
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Sastra SA, Olive KP. Quantification of murine pancreatic tumors by high resolution ultrasound. Methods Mol Biol. 2013;980:249-66. doi: 10.1007/978-1-62703-287-2_13. PMID:23359158
File Size: 2823 kb
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Westphalen CB, Olive KP. Genetically engineered mouse models of pancreatic cancer. Cancer J. 2012 Nov-Dec;18(6):502-10. doi: 10.1097/PPO.0b013e31827ab4c4. Review. PMID:23187836
File Size: 328 kb
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Cox AD, Olive KP. Silencing the killers: paracrine immune suppression in pancreatic cancer. Cancer Cell. 2012 Jun 12;21(6):715-6. doi: 10.1016/j.ccr.2012.05.029. PMID: 22698396
File Size: 212 kb
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Bapiro TE, Richards FM, Goldgraben MA, Olive KP, Madhu B, Frese KK, Cook N, Jacobetz MA, Smith DM, Tuveson DA, Griffiths JR, Jodrell DI. A novel method for quantification of gemcitabine and its metabolites 2',2'-difluorodeoxyuridine and gemcitabine triphosphate in tumour tissue by LC-MS/MS: comparison with (19)F NMR spectroscopy. Cancer Chemother Pharmacol, March 23, 2011. PMID:21431415
File Size: 1883 kb
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Neesse A, Michl P, Frese KK, Feig C, Cook N, Jacobetz MA, Lolkema MP, Buchholz M, Olive KP, Gress TM, Tuveson DA. Stromal biology and therapy in pancreatic cancer.Gut. 2011 Jun;60(6):861-8. doi: 10.1136/gut.2010.226092. Epub 2010 Oct 21. Review. PMID: 20966025
File Size: 782 kb
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Skoulidis F, Cassidy LD, Pisupati V, Jonasson JG, Bjarnason H, Eyfjord JE, Karreth FA, Lim M, Barber LM, Clatworthy SA, Davies SE, Olive KP, Tuveson DA, Venkitaraman AR. Germline Brca2 heterozygosity promotes Kras(G12D)-driven carcinogenesis in a murine model of familial pancreatic cancer. Cancer Cell, 18(5):499-509, 2010. PMID:21056012
File Size: 2493 kb
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Olive KP, Davidson CJ, Jacobetz MA, Honess D, McIntyre D, Madhu B, Goldgraben MA, Frese K, Caldwell ME, DeNicola G, Feig C, Gopinathan A, Combs C, Winter SP, Ireland H, Wang L, Rückert F, Grützmann R, Pilarsky C, Izeradjene K, Hingorani SR, Huang P, Davies SE, Iacobuzio-Donahue C, Plunkett W, Egorin M, Hruban RH, McGovern K, Griffiths J, Tuveson DA. Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer. Science, 324: 1457-1461, 2009. PMID:19460966
File Size: 492 kb
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Bertout JA* & Patel JA*, Fryer BH, Durham AC, Covello KA, Olive KP, Goldschmidt MH, Simon, MC. Heterozygosity for Hypoxia Inducible Factor 1a decreases the incidence of thymic lymphosarcomas in a p53 mutant mouse model. Cancer Research, 69(7): 3213- 3220, 2009. PMID:19293180
File Size: 2278 kb
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Cook N, Olive KP, Frese K, Tuveson DA. K-ras-driven pancreatic cancer mouse model for anticancer inhibitor analyses. Methods in Enzymology, 439: 73 – 85. PMID:18374157
File Size: 306 kb
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Olive KP, Tuveson DA. The use of targeted mouse models for preclinical testing of novel cancer therapeutics. Clin Cancer Res. 2006 Sep 15;12(18):5277-87. Review. PMID: 17000660
File Size: 725 kb
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Jackson EL* & Olive KP*, Tuveson DA, Bronson R, Crowley D, Brown M, Jacks T. The Differential Effects of Mutant p53 Alleles on Advanced Murine Lung Cancer. Cancer Research, 65(22): 10280-10288, 2005. PMID:15607980
File Size: 2417 kb
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Wijnhoven SW, Zwart E, Speksnijder EN, Beems RB, Olive KP, Tuveson DA, Jonkers J, Schaap MM, van den Berg J, Jacks T, van Steeg H, de Vries A. Mice Expressing a Mammary Gland-Specific R270H Mutation in the p53 Tumor Suppressor Gene Mimic Human Breast Cancer Development. Cancer Research, Vol. 65 (18): 8166 – 8173, 2005. PMID:16166291
File Size: 1590 kb
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Olive KP, Tuveson DA, Ruhe ZC, Yin B, Willis NA, Bronson RT, Crowley D, Jacks T. Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell. 2004 Dec 17;119(6):847-60. PMID: 15607980
File Size: 826 kb
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  • Home
  • Science
    • Olive Lab Research
    • Pancreatic Cancer
    • Mouse Hospital
    • The KPC Model
    • Imaging
  • Lab Members
    • Alumni
  • Publications
  • More
    • A non-technical overview >
      • The Pancreas (Overview)
      • Pre-cancerous lesions (Overview)
      • Pancreatic Cancer (Overview)
      • Pancreatic Cancer Statistics
      • Symptoms and Diagnosis
      • Surgery for Pancreatic Cancer (Overview)
      • Drug Treatment (Overview)
      • Mouse Models (Overview)
      • Clinical Trials
    • Donate
    • Facilities >
      • ICRC Building
      • Shared Resources
      • Main Lab
      • Vevo 3100 Ultrasound
    • Join Us!
    • Oncology Precision Therapeutics Core >
      • MRI
      • Ivis Optical Imager
      • Vevo 3100 Ultrasound
      • Perkin-Elmer FX micro CT
    • Photos >
      • 10/30/19 Fall Fun
      • 6/29/18 Jaime's Last Day
      • 9/26/15 Mike's Wedding
      • 11/8/14 Carmine's Wedding
      • 7/7/14 Barbara's Temporary Goodbye Lunch
      • 4/26/13 Korean and Karaoke
      • 4/12/13 Purple Stride
      • 11/26/12 Pancreatic Cancer Awareness Week!!
      • 10/26/12 Pumpkin Carving
      • 9/5-7/2012 Olive and Kimmelman Lab Retreat
      • 7/13/12 Mid-summer BBQ
      • 3/29/12 Jennifer's Goodbye - BoardGame Night
      • 3/8/2012 Barbara's engagement celebration
      • 3/2/2012 Bowling
      • 12/18/2011 Holiday Party
      • 12/9/2011 Poker
      • 11/11/2011 Karaoke
      • 7/15/2011 Holiday Party
    • Support