THE OLIVE LABORATORY
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    • Olive Lab Research
    • Pancreatic Cancer
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    • A non-technical overview >
      • The Pancreas (Overview)
      • Pre-cancerous lesions (Overview)
      • Pancreatic Cancer (Overview)
      • Pancreatic Cancer Statistics
      • Symptoms and Diagnosis
      • Surgery for Pancreatic Cancer (Overview)
      • Drug Treatment (Overview)
      • Mouse Models (Overview)
      • Clinical Trials
    • Donate
    • Facilities >
      • ICRC Building
      • Shared Resources
      • Main Lab
      • Vevo 3100 Ultrasound
    • Join Us!
    • Oncology Precision Therapeutics Core >
      • MRI
      • Ivis Optical Imager
      • Vevo 3100 Ultrasound
      • Perkin-Elmer FX micro CT
    • Photos >
      • 10/30/19 Fall Fun
      • 6/29/18 Jaime's Last Day
      • 9/26/15 Mike's Wedding
      • 11/8/14 Carmine's Wedding
      • 7/7/14 Barbara's Temporary Goodbye Lunch
      • 4/26/13 Korean and Karaoke
      • 4/12/13 Purple Stride
      • 11/26/12 Pancreatic Cancer Awareness Week!!
      • 10/26/12 Pumpkin Carving
      • 9/5-7/2012 Olive and Kimmelman Lab Retreat
      • 7/13/12 Mid-summer BBQ
      • 3/29/12 Jennifer's Goodbye - BoardGame Night
      • 3/8/2012 Barbara's engagement celebration
      • 3/2/2012 Bowling
      • 12/18/2011 Holiday Party
      • 12/9/2011 Poker
      • 11/11/2011 Karaoke
      • 7/15/2011 Holiday Party
    • Support

Research Focus

​Our laboratory is dedicated to finding a cure for Pancreatic Cancer. We perform preclinical trials of novel therapeutics using advanced genetically engineered mouse models of pancreatic cancer. Our research is incredibly collaborative and resourceful using all areas of biology to answer our questions. Our research ranges from in vitro, ex vivo, and in vivo models as well as computational biology to better analyze our data. 

Research Projects

Therapeutically Targeting
​Pancreatic Cancer
Cysteine Metabolism
​and Ferroptosis
RNA Based
​Precision Medicine

About Dr. Ken Olive

Picture
Kenneth P. Olive earned a B.S. from Bucknell University and his PhD from MIT. He joined Columbia in 2010 and 
is an associate professor in the department of medicine and director of the Oncology Precision Therapeutics and Imaging Core (OPTIC) Shared Resource.

Dr. Olive's research is dedicated to finding a cure for pancreatic cancer. The Olive Lab performs preclinical therapeutics trials using advanced genetically engineered mouse models of pancreatic cancer. With an average survival of less than six months, PDA is a uniquely lethal disease that is responsible for the deaths of over 35,000 people annually in the US. 90% of patients present with advanced disease and in most cases, the tumors are innately resistant to chemotherapy. There is great need for advances in the treatment of this disease.

The core of the laboratory is based on a preclinical trials infrastructure called the "Mouse Hospital". This effort seeks to treat mice with pancreatic cancer in exactly the manner that human patients are treated. Tumor volumes are tracked and quantified using advanced small animal imaging technologies such as high-resolution ultrasound and optical imaging, and mice are enrolled into randomized therapeutics trials. Pharmacokinetic and pharmacodynamic analyses, functional imaging, microscopy, biochemistry and molecular biology techniques are employed to assess drug mechanisms and understand relevant signaling pathways. Ultimately, successful therapies will be translated into the clinical settling through our collaborations with the Pancreas Center of Columbia University.

Contact Us

email

kenolive@columbia.edu
​

phone

(212) 851-4507​

address

ICRC
​1130 Saint Nicholas Ave Rm 208C
New York, NY 10032


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  • Home
  • Science
    • Olive Lab Research
    • Pancreatic Cancer
    • Mouse Hospital
    • The KPC Model
    • Imaging
  • Lab Members
    • Alumni
  • Publications
  • More
    • A non-technical overview >
      • The Pancreas (Overview)
      • Pre-cancerous lesions (Overview)
      • Pancreatic Cancer (Overview)
      • Pancreatic Cancer Statistics
      • Symptoms and Diagnosis
      • Surgery for Pancreatic Cancer (Overview)
      • Drug Treatment (Overview)
      • Mouse Models (Overview)
      • Clinical Trials
    • Donate
    • Facilities >
      • ICRC Building
      • Shared Resources
      • Main Lab
      • Vevo 3100 Ultrasound
    • Join Us!
    • Oncology Precision Therapeutics Core >
      • MRI
      • Ivis Optical Imager
      • Vevo 3100 Ultrasound
      • Perkin-Elmer FX micro CT
    • Photos >
      • 10/30/19 Fall Fun
      • 6/29/18 Jaime's Last Day
      • 9/26/15 Mike's Wedding
      • 11/8/14 Carmine's Wedding
      • 7/7/14 Barbara's Temporary Goodbye Lunch
      • 4/26/13 Korean and Karaoke
      • 4/12/13 Purple Stride
      • 11/26/12 Pancreatic Cancer Awareness Week!!
      • 10/26/12 Pumpkin Carving
      • 9/5-7/2012 Olive and Kimmelman Lab Retreat
      • 7/13/12 Mid-summer BBQ
      • 3/29/12 Jennifer's Goodbye - BoardGame Night
      • 3/8/2012 Barbara's engagement celebration
      • 3/2/2012 Bowling
      • 12/18/2011 Holiday Party
      • 12/9/2011 Poker
      • 11/11/2011 Karaoke
      • 7/15/2011 Holiday Party
    • Support