The IVIS spectrum is an imaging technique that uses bioluminescent and fluorescent reporters that can render into a 3 dimensional view of the animal. This technique is noninvasive and can be used for disease progression, monitoring, as well as observing gene expression patterns in vivo. It has high throughput capabilities (5 mice) with a 23 cm field of view. This imaging system creates high resolution images (to 20 microns) with a 3.9 cm field of view. OPTIC currently has 2 IVIS's, one is held in the BSL2 Suites in the Irving Cancer Research Center.