THE OLIVE LABORATORY
  • Home
  • Science
    • Olive Lab Research
    • Pancreatic Cancer
    • Mouse Hospital
    • The KPC Model
    • Imaging
  • Lab Members
    • Alumni
  • Publications
  • More
    • A non-technical overview >
      • The Pancreas (Overview)
      • Pre-cancerous lesions (Overview)
      • Pancreatic Cancer (Overview)
      • Pancreatic Cancer Statistics
      • Symptoms and Diagnosis
      • Surgery for Pancreatic Cancer (Overview)
      • Drug Treatment (Overview)
      • Mouse Models (Overview)
      • Clinical Trials
    • Donate
    • Facilities >
      • ICRC Building
      • Shared Resources
      • Main Lab
      • Vevo 3100 Ultrasound
    • Join Us!
    • Oncology Precision Therapeutics Core >
      • MRI
      • Ivis Optical Imager
      • Vevo 3100 Ultrasound
      • Perkin-Elmer FX micro CT
    • Photos >
      • 10/30/19 Fall Fun
      • 6/29/18 Jaime's Last Day
      • 9/26/15 Mike's Wedding
      • 11/8/14 Carmine's Wedding
      • 7/7/14 Barbara's Temporary Goodbye Lunch
      • 4/26/13 Korean and Karaoke
      • 4/12/13 Purple Stride
      • 11/26/12 Pancreatic Cancer Awareness Week!!
      • 10/26/12 Pumpkin Carving
      • 9/5-7/2012 Olive and Kimmelman Lab Retreat
      • 7/13/12 Mid-summer BBQ
      • 3/29/12 Jennifer's Goodbye - BoardGame Night
      • 3/8/2012 Barbara's engagement celebration
      • 3/2/2012 Bowling
      • 12/18/2011 Holiday Party
      • 12/9/2011 Poker
      • 11/11/2011 Karaoke
      • 7/15/2011 Holiday Party
    • Support

The Mouse Hospital

Picture
https://www.nytimes.com/video/health/100000002273306/inside-a-mouse-hospital.html
The Mouse Hospital infrastructure is a core facility within our laboratory designed to recreate all aspects of a clinical trial while using mouse models. Mice genetically engineered to develop pancreatic cancer are bred centrally and then screened by high resolution ultrasound for the development of spontaneous pancreatic tumors. Tumor volumes are quantified via 3D ultrasound and, upon reaching a predetermined size, the tumor-bearing mice are randomized into treatment groups. The advantage of this core structure is that each week a cohort of roughly synchronized tumors are simultaneously enrolled in a single experiment; this is in contrast to having several smaller project-specific colonies that generate just a few mice per week. The core approach allows the scientists directing each study to focus on other experiments when not enrolling mice, providing increased efficiency of resources, both in terms of material and time. This structure demands a highly cooperative team of researchers and a dedicated staff scientist to manage the core mouse colony and carry out the pre-enrollment screening.

The Mouse Hospital plays a key role in our laboratory's translational research and focus on translational precision medicine. We are able to do this by collaborating with oncologists and surgeons at CUIMC to develop PDX models. The Mouse Hospital is uniquely organized to support the development of PDX models because it is designed to model the clinic.  When our lab receives patient derived tumors it will be divided in several ways depending on the quality and quantity of the sample. Because we are a translational research lab, priority is given to the development of in vivo PDX models. The rest of the pieces are either sent for RNA sequencing, tumor banking, single cell assays, and/or the development of organoids and explants. It is important to note that we stay in compliance with the Institutional Review Board (IRB) when collecting patient samples, as well as the Institutional Animal Care and Use Committee when studying and caring for our animals. It is our priority to stay in compliance with these committees to continue generating ethical data.

The Mouse Hospital core is located in a dedicated procedure room within the barrier facility in the ICRC building. It includes the Vevo 3100 ultrasound instrument, small animal anesthesia apparatus, and areas/equipment for drug preparation/administration and for surgical preparation, operation, and recovery.
Powered by Create your own unique website with customizable templates.
  • Home
  • Science
    • Olive Lab Research
    • Pancreatic Cancer
    • Mouse Hospital
    • The KPC Model
    • Imaging
  • Lab Members
    • Alumni
  • Publications
  • More
    • A non-technical overview >
      • The Pancreas (Overview)
      • Pre-cancerous lesions (Overview)
      • Pancreatic Cancer (Overview)
      • Pancreatic Cancer Statistics
      • Symptoms and Diagnosis
      • Surgery for Pancreatic Cancer (Overview)
      • Drug Treatment (Overview)
      • Mouse Models (Overview)
      • Clinical Trials
    • Donate
    • Facilities >
      • ICRC Building
      • Shared Resources
      • Main Lab
      • Vevo 3100 Ultrasound
    • Join Us!
    • Oncology Precision Therapeutics Core >
      • MRI
      • Ivis Optical Imager
      • Vevo 3100 Ultrasound
      • Perkin-Elmer FX micro CT
    • Photos >
      • 10/30/19 Fall Fun
      • 6/29/18 Jaime's Last Day
      • 9/26/15 Mike's Wedding
      • 11/8/14 Carmine's Wedding
      • 7/7/14 Barbara's Temporary Goodbye Lunch
      • 4/26/13 Korean and Karaoke
      • 4/12/13 Purple Stride
      • 11/26/12 Pancreatic Cancer Awareness Week!!
      • 10/26/12 Pumpkin Carving
      • 9/5-7/2012 Olive and Kimmelman Lab Retreat
      • 7/13/12 Mid-summer BBQ
      • 3/29/12 Jennifer's Goodbye - BoardGame Night
      • 3/8/2012 Barbara's engagement celebration
      • 3/2/2012 Bowling
      • 12/18/2011 Holiday Party
      • 12/9/2011 Poker
      • 11/11/2011 Karaoke
      • 7/15/2011 Holiday Party
    • Support